Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.

ABSTRACT:

Objective

To determine the prognostic utility of tauopathy-associated single nucleotide polymorphisms (SNPs) in sporadic behavioral-variant frontotemporal dementia (bvFTD).

Methods

Eighty-one patients with sporadic bvFTD were genotyped for tauopathy-associated SNPs at rs8070723 (microtubule-associated protein tau [MAPT]) and rs1768208 (myelin-associated oligodendrocyte basic protein [MOBP]). We performed a retrospective case-control study comparing age at onset and disease duration between carriers of ≥1 polymorphism allele and noncarriers for these SNPs. Subanalyses were performed for autopsied subgroups with tauopathy (n = 20) and TDP-43 proteinopathy (n = 12). To identify a potential biological basis for disease duration, neuroimaging measures of white matter integrity we

SUBMITTER: Irwin DJ 

PROVIDER: S-EPMC4141997 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature