White matter correlates of cognitive dysfunction after mild traumatic brain injury.

ABSTRACT:

Objective

To relate neurophysiologic changes after mild/moderate traumatic brain injury to cognitive deficit in a longitudinal diffusion tensor imaging investigation.

Methods

Fifty-three patients were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three patients were rescanned 1 year later. Thirty-three matched control subjects were recruited. At the time of scanning, participants completed cognitive testing. Tract-Based Spatial Statistics was used to conduct voxel-wise analysis on diffusion changes and to explore regressions between diffusion metrics and cognitive performance.

Results

Acutely, increased axial diffusivity drove a fractional anisotropy (FA) increase, while decreased radial diffusivity drove a negative regression between FA and Verb

SUBMITTER: Croall ID 

PROVIDER: S-EPMC4142001 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature