Systematic identification of 3'-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons.

ABSTRACT: Ongoing neuronal activity during development and plasticity acts to refine synaptic connections and contributes to the induction of plasticity and ultimately long-term memory storage. Activity-dependent, post-transcriptional control of mRNAs occurs through transport to axonal and dendritic compartments, local translation and mRNA stability. We have identified a mechanism that contributes to activity-dependent regulation of mRNA stability during synaptic plasticity in rat hippocampal neurons. In this study, we demonstrate rapid, post-transcriptional control over process-enriched mRNAs by neuronal activity. Systematic analysis of the 3'-UTRs of destabilized transcripts, identifies enrichment in sequence motifs corresponding to microRNA (miRNA)-binding sites. The miRNAs that were identified,

SUBMITTER: Cohen JE 

PROVIDER: S-EPMC4142030 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature