Network meta-analysis of multiple outcome measures accounting for borrowing of information across outcomes.

ABSTRACT:

Background

Network meta-analysis (NMA) enables simultaneous comparison of multiple treatments while preserving randomisation. When summarising evidence to inform an economic evaluation, it is important that the analysis accurately reflects the dependency structure within the data, as correlations between outcomes may have implication for estimating the net benefit associated with treatment. A multivariate NMA offers a framework for evaluating multiple treatments across multiple outcome measures while accounting for the correlation structure between outcomes.

Methods

The standard NMA model is extended to multiple outcome settings in two stages. In the first stage, information is borrowed across outcomes as well across studies through modelling the within-study and between-stu

SUBMITTER: Achana FA 

PROVIDER: S-EPMC4142066 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature