Mutational landscape of candidate genes in familial prostate cancer.

ABSTRACT:

Background

Family history is a major risk factor for prostate cancer (PCa), suggesting a genetic component to the disease. However, traditional linkage and association studies have failed to fully elucidate the underlying genetic basis of familial PCa.

Methods

Here, we use a candidate gene approach to identify potential PCa susceptibility variants in whole exome sequencing data from familial PCa cases. Six hundred ninety-seven candidate genes were identified based on function, location near a known chromosome 17 linkage signal, and/or previous association with prostate or other cancers. Single nucleotide variants (SNVs) in these candidate genes were identified in whole exome sequence data from 33 PCa cases from 11 multiplex PCa families (3 cases/family).

Results

Overa

SUBMITTER: Johnson AM 

PROVIDER: S-EPMC4142071 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature