The interrelations among stochastic pacing, stability, and memory in the heart.

ABSTRACT: Low pacing variability in the heart has been clinically reported as a risk factor for lethal cardiac arrhythmias and arrhythmic death. In ia previous simulation study, we demonstrated that stochastic pacing sustains an antiarrhythmic effect by moderating the slope of the action potential duration (APD) restitution curve, by reducing the propensity of APD alternans, converting discordant to concordant alternans, and ultimately preventing wavebreaks. However, the dynamic mechanisms relating pacing stochasticity to tissue stability are not yet known. In this work, we develop a mathematical framework to describe the APD signal using an autoregressive stochastic model, and we establish the interrelations between stochastic pacing, cardiac memory, and cardiac stability, as manifested by the degr

SUBMITTER: Dvir H 

PROVIDER: S-EPMC4142253 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature