Novel approach for coexpression analysis of E2F1-3 and MYC target genes in chronic myelogenous leukemia.

ABSTRACT:

Background

Chronic myelogenous leukemia (CML) is characterized by tremendous amount of immature myeloid cells in the blood circulation. E2F1-3 and MYC are important transcription factors that form positive feedback loops by reciprocal regulation in their own transcription processes. Since genes regulated by E2F1-3 or MYC are related to cell proliferation and apoptosis, we wonder if there exists difference in the coexpression patterns of genes regulated concurrently by E2F1-3 and MYC between the normal and the CML states.

Results

We proposed a method to explore the difference in the coexpression patterns of those candidate target genes between the normal and the CML groups. A disease-specific cutoff point for coexpression levels that classified the coexpressed gene pairs into

SUBMITTER: Wang F 

PROVIDER: S-EPMC4142389 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature