Sugammadex is effective in reversing rocuronium in the presence of antibiotics.

ABSTRACT:

Background

The effectiveness of sugammadex in reversing rocuronium-induced neuromuscular blockade (NMB) in the presence of drugs that may potentiate NMB remains to be fully established. The aim of this post-hoc analysis of data from a Phase III clinical trial (VISTA; NCT00298831) was to investigate the impact of antibiotics on recovery from rocuronium-induced NMB after administration of sugammadex for reversal, and compared the neuromuscular recovery in patients who received antibiotics preoperatively with those who did not.

Methods

A Phase III, multicenter, open-label study designed to reflect potential use of sugammadex in clinical practice was conducted at 19 sites. Data obtained from patients who received antibiotics were compared with the cohort of patients who underwen

SUBMITTER: Hudson ME 

PROVIDER: S-EPMC4142447 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature