Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure.

ABSTRACT:

Background

Injury due to myocardial infarction (MI) is largely irreversible. Once an infarct has occurred, the clinical goal becomes limiting remodeling, preserving left ventricular function, and preventing heart failure. Although traditional approaches (e.g., β-blockers) partially preserve left ventricular function, novel strategies are needed to limit ventricular remodeling post-MI.

Objectives

The aim of this study was to determine the role of glycogen synthase kinase-3α (GSK-3α) in post-MI remodeling.

Methods

Mice with cardiomyocyte-specific conditional deletion of Gsk3α and littermate controls underwent sham or MI surgery. Heart function was assessed using serial M-mode echocardiography.

Results

Gsk3α deletion in the heart markedly limits remodeling and pre

SUBMITTER: Ahmad F 

PROVIDER: S-EPMC4142642 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature