Memantine enhances recovery from stroke.

ABSTRACT:

Background and purpose

Stroke treatment is constrained by limited treatment windows and the clinical inefficacy of agents that showed preclinical promise. Yet animal and clinical data suggest considerable poststroke plasticity, which could allow treatment with recovery-modulating agents. Memantine is a well-tolerated N-methyl-D-aspartate glutamate receptor antagonist in common use for Alzheimer disease.

Methods

Memantine, 30 mg/kg per day, or vehicle, was delivered chronically in drinking water beginning >2 hours after photothrombotic stroke.

Results

Although there was no difference in infarct size, behavior, or optical intrinsic signal maps in the first 7 days after stroke, mice treated chronically with memantine showed significant improvements in motor control, meas

SUBMITTER: Lopez-Valdes HE 

PROVIDER: S-EPMC4142682 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature