Rapid and tunable post-translational coupling of genetic circuits.

ABSTRACT: One promise of synthetic biology is the creation of genetic circuitry that enables the execution of logical programming in living cells. Such 'wet programming' is positioned to transform a wide and diverse swathe of biotechnology ranging from therapeutics and diagnostics to water treatment strategies. Although progress in the development of a library of genetic modules continues apace, a major challenge for their integration into larger circuits is the generation of sufficiently fast and precise communication between modules. An attractive approach is to integrate engineered circuits with host processes that facilitate robust cellular signalling. In this context, recent studies have demonstrated that bacterial protein degradation can trigger a precise response to stress by overloading a li

SUBMITTER: Prindle A 

PROVIDER: S-EPMC4142690 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature