Repositioning drugs for inflammatory disease - fishing for new anti-inflammatory agents.

ABSTRACT: Inflammation is an important and appropriate host response to infection or injury. However, dysregulation of this response, with resulting persistent or inappropriate inflammation, underlies a broad range of pathological processes, from inflammatory dermatoses to type 2 diabetes and cancer. As such, identifying new drugs to suppress inflammation is an area of intense interest. Despite notable successes, there still exists an unmet need for new effective therapeutic approaches to treat inflammation. Traditional drug discovery, including structure-based drug design, have largely fallen short of satisfying this unmet need. With faster development times and reduced safety and pharmacokinetic uncertainty, drug repositioning - the process of finding new uses for existing drugs - is emerging as a

SUBMITTER: Hall CJ 

PROVIDER: S-EPMC4142727 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature