Circulating levels of 25-hydroxyvitamin D and acute cellular rejection in kidney allograft recipients.

ABSTRACT:

Background

Vitamin D, in addition to its established role in bone metabolism, may regulate the immune system and affect the outcome of allografts.

Methods

We identified 351 kidney allograft recipients who had serum levels of 25-hydroxyvitamin D (25[OH]D) measured within the first 30 days of transplantation. We evaluated the relationship between the circulating levels of 25(OH)D and acute cellular rejection (ACR), cytomegalovirus (CMV) disease, BK virus nephropathy, and kidney graft function.

Results

Vitamin D deficiency (circulating levels of 25[OH]D ≤20 ng/mL, defined using The Endocrine Society Clinical Practice 2011 Guideline) was observed in 216 (61.5%) of 351 kidney graft recipients. Vitamin D deficiency was more frequent in female recipients (P=0.007, Fisher exa

SUBMITTER: Lee JR 

PROVIDER: S-EPMC4142757 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature