Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia.

ABSTRACT:

Aims

Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to investigate hypoxia-induced miR-210 regulation and its role in a mouse model of hindlimb ischemia.

Results

miR-210 expression was induced by femoral artery dissection. To study the role of miR-210, its function was inhibited by the systemic administration of a miR-210 complementary locked nucleic acid (LNA)-oligonucleotide (anti-miR-210). In the ischemic skeletal muscle, anti-miR-210 caused a marked decrease of miR-210 compared with LNA-scramble control, while miR-210 target expression increased accordingly

SUBMITTER: Zaccagnini G 

PROVIDER: S-EPMC4142832 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature