Translation Elongation Rate Measurement of Epstein-Barr Virus Strain GD1.

ABSTRACT:

Background

Epstein-Barr Virus (EBV) has a great co relationship with human malignancies such as gastric carcinoma. Synonymous codon investigations in viruses could help designing vaccine, to generate immunity. Codon Adaptation Index (CAI) has measured translation elongation rate, among the highly expressed genes. The aim of this study was: usage of "CAI" to measure translation efficiency to know how fast EBV-GD1 could produce its proteins.

Methods

The complete genomic sequences of human herpes virus 4 strain GD1 have retrieved from (GenBank accession no. AY961628) to extract all protein-coding genes. The sequences have analyzed with DAMBE software.

Results

The results have shown that CAI values for the EBV-GD1 genes were 0.76

SUBMITTER: Motalleb G 

PROVIDER: S-EPMC4142932 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature