Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains.

ABSTRACT:

Background

Two features of alcohol addiction that have been widely studied in animal models are relapse drinking following periods of alcohol abstinence and the escalation of alcohol consumption after chronic continuous or intermittent alcohol exposure. The genetic contribution to these phenotypes has not been systematically investigated.

Methods

HXB/BXH recombinant inbred (RI) rat strains were given access to alcohol sequentially as follows: alcohol (10%) as the only fluid for 1 week; alcohol (10%) and water in a 2-bottle choice paradigm for 7 weeks ("pre-alcohol deprivation effect [ADE] alcohol consumption"); 2 weeks of access to water only (alcohol deprivation); and 2 weeks of reaccess to 10% alcohol and water ("post-ADE alcohol consumption"). The periods of deprivation a

SUBMITTER: Vanderlinden LA 

PROVIDER: S-EPMC4142977 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature