Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial.

ABSTRACT:

Background

Whether high-dose multivitamins are effective for secondary prevention of atherosclerotic disease is unknown.

Objective

To assess whether oral multivitamins reduce cardiovascular events and are safe.

Design

Double-blind, placebo-controlled, 2 x 2 factorial, multicenter, randomized trial. (ClinicalTrials.gov: NCT00044213) SETTING: 134 U.S. and Canadian academic and clinical sites.

Patients

1708 patients aged 50 years or older who had myocardial infarction (MI) at least 6 weeks earlier and had serum creatinine levels of 176.8 mol/L (2.0 mg/dL) or less.

Intervention

Patients were randomly assigned to an oral, 28-component, high-dose multivitamin and multimineral mixture or placebo.

Measurements

The primary end point was time to total death

SUBMITTER: Lamas GA 

PROVIDER: S-EPMC4143134 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature