A meta-analysis of cognitive impairment following adult cancer chemotherapy.

ABSTRACT:

Objective

Chemotherapy-induced cognitive impairments are reported by many cancer survivors. Research to date has not provided a clear description of their nature, extent, mechanisms, and duration. To investigate the impairments and factors that could influence their identification and severity, the present meta-analysis brings together research on this topic in adult cancer patients.

Method

Our random-model meta-analysis includes 44 studies investigating the cognitive performance of adults treated with chemotherapy for non-central nervous system malignancies, primarily breast and testicular cancer. We conducted several subgroup analyses to identify the level of cognitive impairments in longitudinal and cross-sectional studies. We also pursued several multilevel model regress

SUBMITTER: Lindner OC 

PROVIDER: S-EPMC4143183 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature