A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster.

ABSTRACT: Unraveling the biological information within the regulatory region (RR) of genes has become one of the major focuses of current genomic research. It has been hypothesized that RRs of co-expressed genes share similar architecture, but to the best of our knowledge, no studies have simultaneously examined multiple structural features, such as positioning of cis-regulatory elements relative to transcription start sites and to each other, and the order and orientation of regulatory motifs, to accurately describe overall cis-regulatory structure. In our work we present an improved computational method that builds a feature collection based on all of these structural features. We demonstrate the utility of this approach by modeling the cis-regulatory modules of antenna-expressed genes in Drosophi

SUBMITTER: Lopez Y 

PROVIDER: S-EPMC4143197 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature