Prioritizing candidate disease metabolites based on global functional relationships between metabolites in the context of metabolic pathways.

ABSTRACT: Identification of key metabolites for complex diseases is a challenging task in today's medicine and biology. A special disease is usually caused by the alteration of a series of functional related metabolites having a global influence on the metabolic network. Moreover, the metabolites in the same metabolic pathway are often associated with the same or similar disease. Based on these functional relationships between metabolites in the context of metabolic pathways, we here presented a pathway-based random walk method called PROFANCY for prioritization of candidate disease metabolites. Our strategy not only takes advantage of the global functional relationships between metabolites but also sufficiently exploits the functionally modular nature of metabolic networks. Our approach proved succ

SUBMITTER: Shang D 

PROVIDER: S-EPMC4143229 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature