Molecular and evolutionary analysis of NEAr-iron Transporter (NEAT) domains.

ABSTRACT: Iron is essential for bacterial survival, being required for numerous biological processes. NEAr-iron Transporter (NEAT) domains have been studied in pathogenic Gram-positive bacteria to understand how their proteins obtain heme as an iron source during infection. While a 2002 study initially discovered and annotated the NEAT domain encoded by the genomes of several Gram-positive bacteria, there remains a scarcity of information regarding the conservation and distribution of NEAT domains throughout the bacterial kingdom, and whether these domains are restricted to pathogenic bacteria. This study aims to expand upon initial bioinformatics analysis of predicted NEAT domains, by exploring their evolution and conserved function. This information was used to identify new candidate domains in bo

SUBMITTER: Honsa ES 

PROVIDER: S-EPMC4143258 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature