Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.

ABSTRACT: End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective.

SUBMITTER: Sunshine J 

PROVIDER: S-EPMC4143259 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature