OptMAVEn--a new framework for the de novo design of antibody variable region models targeting specific antigen epitopes.

ABSTRACT: Antibody-based therapeutics provides novel and efficacious treatments for a number of diseases. Traditional experimental approaches for designing therapeutic antibodies rely on raising antibodies against a target antigen in an immunized animal or directed evolution of antibodies with low affinity for the desired antigen. However, these methods remain time consuming, cannot target a specific epitope and do not lead to broad design principles informing other studies. Computational design methods can overcome some of these limitations by using biophysics models to rationally select antibody parts that maximize affinity for a target antigen epitope. This has been addressed to some extend by OptCDR for the design of complementary determining regions. Here, we extend this earlier contribution by

SUBMITTER: Li T 

PROVIDER: S-EPMC4143332 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature