Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.

ABSTRACT: Filamentous inclusions of the microtubule-associated protein, tau, define a variety of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To better understand the role of tau-mediated effects on pathophysiology and global central nervous system function, we extensively characterized gene expression, pathology and behavior of the rTg4510 mouse model, which overexpresses a mutant form of human tau that causes Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). We found that the most predominantly altered gene expression pathways in rTg4510 mice were in inflammatory processes. These results closely matched the causal immune function and microglial gene-regulatory network recently identified in AD. We identified additional gene expressi

SUBMITTER: Wes PD 

PROVIDER: S-EPMC4143352 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature