The causal nature of the association between neighborhood deprivation and drug abuse: a prospective national Swedish co-relative control study.

ABSTRACT:

Background

Risk for drug abuse (DA) is strongly associated with neighborhood social deprivation (SD). However, the causal nature of this relationship is unclear.

Method

Three Swedish population-based cohorts were followed up over 5 years for incident registration of DA in medical, legal or pharmacy records. In each cohort, we examined the SD-DA association, controlling carefully for individual socio-economic status (SES) with multiple measures, in the entire sample and among pairs of first cousins, paternal and maternal half-siblings, full siblings and monozygotic (MZ) twins discordant for SD exposure. The number of informative relative pairs ranged from 6366 to 166,208.

Results

In all cohorts, SD was prospectively related to risk for incident DA. In relative pairs di

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC4143383 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature