Serum testosterone levels and mortality in men with CKD stages 3-4.

ABSTRACT:

Background

Hypogonadism in men (total testosterone <350 ng/dL) is associated with higher risk of cardiovascular disease and mortality in men on dialysis therapy. We evaluated the association of hypogonadism with all-cause mortality in men with non-dialysis-dependent chronic kidney disease (CKD).

Study design

Retrospective, cohort study.

Setting & participants

2,419 men with CKD stages 3-4 (estimated glomerular filtration rate, 15-59 mL/min/1.73 m2) who had total testosterone measured for cause between January 1, 2005, and October 31, 2011, at a tertiary-care center in Cleveland, OH.

Predictors

Total testosterone measured using an immunoassay measurement in 3 forms: (1) categorized as low or testosterone replacement therapy versus normal, (2) continuous log test

SUBMITTER: Khurana KK 

PROVIDER: S-EPMC4143431 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature