Troponin I and NT-proBNP and the association of systolic blood pressure with outcomes in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study.

ABSTRACT:

Background

There is uncertainty regarding treatment of hypertension in hemodialysis patients due to the observed J-shaped association between blood pressure (BP) and death. We hypothesized that this association reflects confounding by cardiovascular disease (CVD) and that stratification by CVD biomarkers, cardiac troponin I (cTnI) and N-terminal fragment of prohormone brain natriuretic peptide (NT-proBNP), might change this association.

Study design

National prospective cohort study.

Setting & participants

446 incident hemodialysis patients.

Predictor

Predialysis systolic BP.

Outcomes

Mortality (all-cause and CVD) and first CVD event assessed using Cox regression adjusted for demographics, comorbid conditions, and clinical factors.

Measurements

Pa

SUBMITTER: Shafi T 

PROVIDER: S-EPMC4143435 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature