Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics.

ABSTRACT:

Background and purpose

Smoking greatly increases the risk of atherosclerotic plaque and the effect may vary from individual to individual. A genome-wide scan was performed for smoking×single nucleotide polymorphism (SNP) interactions on carotid plaque burden (CPB) to identify the potential genetic moderators in Hispanics.

Methods

Carotid B-mode ultrasonography and genotyping by the Affymetrix 6.0 chip were performed in a discovery sample of 665 Caribbean Hispanics, followed by replication analyses in 264 Caribbean Hispanics. CPB was expressed as the sum of plaque areas over the segments in common and internal carotid arteries and bifurcation. Smoking was classified as 0, <20, and ≥20 cigarette pack-years. Assuming an additive genetic model, regression analysis was conducted

SUBMITTER: Della-Morte D 

PROVIDER: S-EPMC4143440 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature