Personalized medicine for the management of benign prostatic hyperplasia.

ABSTRACT:

Purpose

Benign prostatic hyperplasia affects more than 50% of men by age 60 years, and is the cause of millions of dollars in health care expenditure for the treatment of lower urinary tract symptoms and urinary obstruction. Despite the widespread use of medical therapy, there is no universal therapy that treats all men with symptomatic benign prostatic hyperplasia. At least 30% of patients do not respond to medical management and a subset require surgery. Significant advances have been made in understanding the natural history and development of the prostate, such as elucidating the role of the enzyme 5α-reductase type 2, and advances in genomics and biomarker discovery offer the potential for a more targeted approach to therapy. We review the current understanding of benign prost

SUBMITTER: Bechis SK 

PROVIDER: S-EPMC4143483 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature