CGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

ABSTRACT: Detection of cytoplasmic DNA represents one of the most fundamental mechanisms of the innate immune system to sense the presence of microbial pathogens. Moreover, erroneous detection of endogenous DNA by the same sensing mechanisms has an important pathophysiological role in certain sterile inflammatory conditions. The endoplasmic-reticulum-resident protein STING is critically required for the initiation of type I interferon signalling upon detection of cytosolic DNA of both exogenous and endogenous origin. Next to its pivotal role in DNA sensing, STING also serves as a direct receptor for the detection of cyclic dinucleotides, which function as second messenger molecules in bacteria. DNA recognition, however, is triggered in an indirect fashion that depends on a recently characterized cyt

SUBMITTER: Ablasser A 

PROVIDER: S-EPMC4143541 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature