Testing for associations between systolic blood pressure and single-nucleotide polymorphism profiles obtained from sparse principal component analysis.

ABSTRACT:

Background

Hypertension is a prevalent condition linked to major cardiovascular conditions and multiple other comorbidities. Genetic information can offer a deeper understanding about susceptibility and the underlying disease mechanisms. The Genetic Analysis Workshop 18 (GAW18) provides abundant genotype data to determine genetic associations for being hypertensive and for the underlying trait of systolic blood pressure (SBP). The high-dimensional nature of this data promotes dimension reduction techniques to remove excess noise and also synthesize genetic information for complex, polygenic traits.

Methods

For both measured and simulated phenotype data from GAW18, we use sparse principal component analysis to obtain sparse genetic profiles that represent the underlying data

SUBMITTER: Bonner A 

PROVIDER: S-EPMC4143624 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature