Genotype imputation accuracy with different reference panels in admixed populations.

ABSTRACT: Genome-wide association studies have successfully identified common variants that are associated with complex diseases. However, the majority of genetic variants contributing to disease susceptibility are yet to be discovered. It is now widely believed that multiple rare variants are likely to be associated with complex diseases. Using custom-made chips or next-generation sequencing to uncover the effects of rare variants on the disease can be very expensive in current technology. Consequently, many researchers use the genotype imputation approach to predict the genotypes at these rare variants that are not directly genotyped in the study sample. One important question in genotype imputation is how to choose a reference panel that will produce high imputation accuracy in a population of in

SUBMITTER: Huang GH 

PROVIDER: S-EPMC4143631 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature