Discovering pure gene-environment interactions in blood pressure genome-wide association studies data: a two-step approach incorporating new statistics.

ABSTRACT: Environment has long been known to play an important part in disease etiology. However, not many genome-wide association studies take environmental factors into consideration. There is also a need for new methods to identify the gene-environment interactions. In this study, we propose a 2-step approach incorporating an influence measure that capturespure gene-environment effect. We found that pure gene-age interaction has a stronger association than considering the genetic effect alone for systolic blood pressure, measured by counting the number of single-nucleotide polymorphisms (SNPs)reaching a certain significance level. We analyzed the subjects by dividing them into two age groups and found no overlap in the top identified SNPs between them. This suggested that age might have a nonline

SUBMITTER: Wang MH 

PROVIDER: S-EPMC4143689 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature