Analysis of the progression of systolic blood pressure using imputation of missing phenotype values.

ABSTRACT: We present a genome-wide association study of a quantitative trait, "progression of systolic blood pressure in time," in which 142 unrelated individuals of the Genetic Analysis Workshop 18 real genotype data were analyzed. Information on systolic blood pressure and other phenotypic covariates was missing at certain time points for a considerable part of the sample. We observed that the dropout process causing missingness is not independent of the initial systolic blood pressure; that is, the data is not missing completely at random. However, after the adjustment for age, the impact of systolic blood pressure on dropouts was no longer significant. Therefore, we decided to impute missing phenotype values by using information from individuals with complete phenotypic data. Progression of syst

SUBMITTER: Vaitsiakhovich T 

PROVIDER: S-EPMC4143701 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature