Entropy-based method for assessing the influence of genetic markers and covariates on hypertension: application to Genetic Analysis Workshop 18 data.

ABSTRACT: Many complex diseases are related to genetics, and it is of great interest to evaluate the association between single-nucleotide polymorphisms (SNPs) and disease outcome. The association of genetics with outcome can be modified by covariates such as age, sex, smoking status, and membership to the same pedigree. In this paper, we propose a block entropy method to separate two classes of SNPs, for which the association with hypertension is either sensitive or insensitive to the covariates. We also propose a consistency entropy method to further reduce the number of SNPs that might be associated with the outcome. Based on the data provided by the organizers of Genetic Analysis Workshop 18, we calculated the block entropies for six different blocking strategies. Using block entropy and consist

SUBMITTER: Liu J 

PROVIDER: S-EPMC4143731 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature