A comparison of two collapsing methods in different approaches.

ABSTRACT: Sequencing technologies have enabled the investigation of whole genomes of many individuals in parallel. Studies have shown that the joint consideration of multiple rare variants may explain a relevant proportion of the genetic basis for disease so that grouping of rare variants, termed collapsing, can enrich the association signal. Following this assumption, we investigate the type I error and the power of two proposed collapsing methods (combined multivariate and collapsing method and the functional principal component analysis [FPCA]-based statistic) using the case-control data provided for the Genetic Analysis Workshop 18 with knowledge of the true model. Variants with a minor allele frequency (MAF) of 0.05 or less were collapsed per gene for combined multivariate and collapsing. Neith

SUBMITTER: Dering C 

PROVIDER: S-EPMC4143760 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature