Genetics of obsessive-compulsive disorder and related disorders.

ABSTRACT: Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

SUBMITTER: Browne HA 

PROVIDER: S-EPMC4143777 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature