A novel transmission-based test of association for multivariate phenotypes: an application to systolic and diastolic blood pressure levels.

ABSTRACT: Unlike case-control studies, family-based tests for association are protected against population stratification. Complex genetic traits are often governed by quantitative precursors and it has been argued that it may be a more powerful strategy to analyze these quantitative precursors instead of the clinical end point trait. Although methods have been developed for family-based association tests for single quantitative traits, it is of interest to develop such methods for multivariate phenotypes. We propose a novel transmission-based approach based on a trio design using a simple logistic regression to test for association with a multivariate phenotype. We use our proposed method to analyze data on systolic and diastolic blood pressure levels provided in Genetic Analysis Workshop 18. Howev

SUBMITTER: Haldar T 

PROVIDER: S-EPMC4143884 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature