Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity.

ABSTRACT: Inflammation has a key role in the pathogenesis of various human diseases. The early detection, localization and monitoring of inflammation are crucial for tailoring individual therapies. However, reliable biomarkers to detect local inflammatory activities and to predict disease outcome are still missing. Alarmins, which are locally released during cellular stress, are early amplifiers of inflammation. Here, using optical molecular imaging, we demonstrate that the alarmin S100A8/S100A9 serves as a sensitive local and systemic marker for the detection of even sub-clinical disease activity in inflammatory and immunological processes like irritative and allergic contact dermatitis. In a model of collagen-induced arthritis, we use S100A8/S100A9 imaging to predict the development of disease act

SUBMITTER: Vogl T 

PROVIDER: S-EPMC4143994 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature