Low bone mineral mass is associated with decreased bone formation and diet in girls with Rett syndrome.

ABSTRACT:

Objective

The aim of the present study was to characterize biomarkers of bone turnover and their relation with bone mineral mass in a cross-sectional cohort of girls with Rett syndrome (RTT) and to examine the role of dietary, biochemical, hormonal, and inflammatory factors on bone mineral mass and bone biomarkers in this disorder.

Methods

Total body bone mineral content (BMC) and bone mineral density (BMD) were determined by dual-energy x-ray absorptiometry. Dietary nutrient intakes were determined from 3-day food records. Biomarkers of bone turnover, bone metabolites, vitamin D metabolites, hormones, and inflammatory markers were measured by standard clinical laboratory methods.

Results

Serum osteocalcin, bone alkaline phosphatase, and C-telopeptide showed significa

SUBMITTER: Motil KJ 

PROVIDER: S-EPMC4144049 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature