Measuring exposure to the polyphenol metabolome in observational epidemiologic studies: current tools and applications and their limits.

ABSTRACT: Much experimental evidence supports a protective role of dietary polyphenols against chronic diseases such as cardiovascular diseases, diabetes, and cancer. However, results from observational epidemiologic studies are still limited and are often inconsistent. This is largely explained by the difficulties encountered in the estimation of exposure to the polyphenol metabolome, which is composed of ~500 polyphenols distributed across a wide variety of foods and characterized by diverse biological properties. Exposure to the polyphenol metabolome in epidemiologic studies can be assessed by the use of detailed dietary questionnaires or the measurement of biomarkers of polyphenol intake. The questionnaire approach has been greatly facilitated by the use of new databases on polyphenol compositio

SUBMITTER: Zamora-Ros R 

PROVIDER: S-EPMC4144095 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature