Conductive olfactory losses in chronic rhinosinusitis? A computational fluid dynamics study of 29 patients.

ABSTRACT:

Background

Besides sensorineural factors, conductive impediments likely contribute to olfactory losses in chronic rhinosinusitis (CRS) patients, yet no conclusive evidence exists. We aimed to examine possible conductive factors using computational fluid dynamics (CFD) models.

Methods

A total of 29 CRS patients were assessed via odorant detection thresholds (ODTs), rhinomanometry (nasal resistance [NR]), acoustic rhinometry (minimum-cross-sectional area [MCA]) and computed tomography (CT) staging. CFD simulations of nasal airflow and odorant absorption to olfactory region were carried out based on individual CTs. Biopsies of olfactory epithelium (OE) were collected, cryosectioned, stained, and scored for erosion.

Results

Significant correlations to ODTs were found for

SUBMITTER: Zhao K 

PROVIDER: S-EPMC4144185 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature