Postischemic reperfusion causes smooth muscle calcium sensitization and vasoconstriction of parenchymal arterioles.

ABSTRACT:

Background and purpose

Parenchymal arterioles (PAs) are high-resistance vessels in the brain that connect pial vessels to the microcirculation. We previously showed that PAs have increased vasoconstriction after ischemia and reperfusion that could increase perfusion deficit. Here, we investigated underlying mechanisms by which early postischemic reperfusion causes increased vasoconstriction of PAs.

Methods

Isolated and pressurized PAs from within the middle cerebral artery territory were studied in male Wistar rats that were either nonischemic control (n=34) or after exposure to transient middle cerebral artery occlusion (MCAO) by filament occlusion for 2 hours with 30 minutes of reperfusion (MCAO; n=38). The relationships among pressure-induced tone, smooth muscle calcium (

SUBMITTER: Cipolla MJ 

PROVIDER: S-EPMC4144269 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature