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The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides.

ABSTRACT: Several cycloaddition catalysts and reagents were surveyed for their effectiveness toward cyclizing alkynenitriles with cyanamides. Catalytic amounts of FeI2, (iPr)PDAI and Zn were found to effectively catalyze the [2+2+2] cycloaddition of a variety of cyanamides and alkynenitriles to afford bicyclic 2-aminopyrimidines.

SUBMITTER: Lane TK

PROVIDER: S-EPMC4144345 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides.

Lane Timothy K TK Nguyen Minh H MH D'Souza Brendan R BR Spahn Nathan A NA Louie Janis J

Chemical communications (Cambridge, England) 20130901 70

Several cycloaddition catalysts and reagents were surveyed for their effectiveness toward cyclizing alkynenitriles with cyanamides. Catalytic amounts of FeI2, (iPr)PDAI and Zn were found to effectively catalyze the [2+2+2] cycloaddition of a variety of cyanamides and alkynenitriles to afford bicyclic 2-aminopyrimidines. ...[more]

PMID: 23877441

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