Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation.

ABSTRACT:

Aims

Human atrial electrophysiology exhibits high inter-subject variability in both sinus rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely investigated in experimental and theoretical electrophysiological studies, thus hampering the understanding of its underlying causes but also its implications in explaining differences in the response to disease and treatment. In our study, we aim at investigating the ability of populations of human atrial cell models to capture the inter-subject variability in action potential (AP) recorded in 363 patients both under SR and cAF conditions.

Methods and results

Human AP recordings in atrial trabeculae (n = 469) from SR and cAF patients were used to calibrate populations of computational SR and cAF a

SUBMITTER: Sanchez C 

PROVIDER: S-EPMC4144914 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature