Evaluation of optic nerve development in preterm and term infants using handheld spectral-domain optical coherence tomography.

ABSTRACT:

Purpose

To evaluate effects of prematurity on early optic nerve (ON) development and the usefulness of ON parameters as indicators of central nervous system (CNS) development and pathology.

Design

Prospective, cross-sectional, longitudinal study.

Participants

Forty-four preterm infants undergoing retinopathy of prematurity (ROP) screening and 52 term infants.

Methods

We analyzed ON from portable handheld spectral-domain optical coherence tomography (SD-OCT) images (Bioptigen, Inc, Research Triangle Park, NC) of 44 preterm and 52 term infants. The highest-quality ON scan from either eye was selected for quantitative analysis. Longitudinal analysis was performed at 31-36 weeks and 37-42 weeks postmenstrual age (PMA). Preterm ON parameters also were assessed for c

SUBMITTER: Tong AY 

PROVIDER: S-EPMC4145027 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature