Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome.

ABSTRACT:

Objective

Neonatal abstinence syndrome (NAS) from in utero opioid exposure is highly variable with genetic factors appearing to play an important role. Epigenetic changes in cytosine:guanine (CpG) dinucleotide methylation can occur after drug exposure and may help to explain NAS variability. We correlated DNA methylation levels in the mu-opioid receptor (OPRM1) promoter in opioid-exposed infants with NAS outcomes.

Study design

DNA samples from cord blood or saliva were analyzed for 86 infants who were being treated for NAS according to institutional protocol. Methylation levels at 16 OPRM1 CpG sites were determined and correlated with NAS outcome measures, including need for treatment, treatment with ≥ 2 medications, and length of hospital stay. We adjusted for covariates an

SUBMITTER: Wachman EM 

PROVIDER: S-EPMC4145036 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature