Fetal striatal grafting slows motor and cognitive decline of Huntington's disease.

ABSTRACT:

Objective

To assess the clinical effect of caudate-putaminal transplantation of fetal striatal tissue in Huntington's disease (HD).

Methods

We carried out a follow-up study on 10 HD transplanted patients and 16 HD not-transplanted patients. All patients were evaluated with the Unified HD Rating Scale (UHDRS) whose change in motor, cognitive, behavioural and functional capacity total scores were considered as outcome measures. Grafted patients also received morphological and molecular neuroimaging.

Results

Patients were followed-up from disease onset for a total of 309.3 person-years (minimum 5.3, median 11.2 years, maximum 21.6 years). UHDRS scores have been available since 2004 (median time of 5.7 years since onset, minimum zero, maximum 17.2 years). Median post-tran

SUBMITTER: Paganini M 

PROVIDER: S-EPMC4145428 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature