Vitamin D treatment in calcium-deficiency rickets: a randomised controlled trial.

ABSTRACT:

Objective

To determine whether children with calcium-deficiency rickets have a better response to treatment with vitamin D and calcium than with calcium alone.

Design

Randomised controlled trial.

Setting

Jos University Teaching Hospital, Jos, Nigeria.

Population

Nigerian children with active rickets treated with calcium carbonate as limestone (approximately 938 mg elemental calcium twice daily) were, in addition, randomised to receive either oral vitamin D2 50,000 IU (Ca+D, n=44) or placebo (Ca, n=28) monthly for 24 weeks.

Main outcome measure

Achievement of a 10-point radiographic severity score ≤1.5 and serum alkaline phosphatase ≤350 U/L.

Results

The median (range) age of enrolled children was 46 (15-102) months, and baseline characteristics we

SUBMITTER: Thacher TD 

PROVIDER: S-EPMC4145444 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature