Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility.

ABSTRACT:

Aim

To identify the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms and gastric cancer (GC) susceptibility.

Methods

Systematic searches were performed on the electronic databases PubMed, ISI, Web of knowledge, CNKI and Wanfang, as well as manual searching of the references of the identified articles. A total of 26 papers were included in this meta-analysis. Overall and subgroup analyses were performed. Odds ratio (OR) and 95%CI were used to evaluate the associations between MTHFR polymorphisms and GC risk. The I (2) statistics were used to evaluate between-study heterogeneity. Sensitivity analysis was also performed.

Results

Increased risk was found for the MTHFR C677T polymorphism under four genetic models (TT + CT vs CC: OR = 1.23, P =

SUBMITTER: Xia LZ 

PROVIDER: S-EPMC4145786 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature